Programme

 

PROGRAMME OVERVIEW



1st Jean Hanson Keynote Lecture

Prof Malcolm Irving FRS

Randall Centre for Cell and Molecular Biophysics, BHF Centre of Research Excellence, King’s College London, London, UK



Keynote Lecture

Prof Jil C. Tardiff

Sarver Heart Center, Department of Medicine, University of Arizona, Tucson, AZ, USA



Keynote Lecture

Prof Nadia Rosenthal

The Jackson Laboratory, Bar Harbor, ME, USA and NHLI, Imperial College London, ICTEM, London, UK



SESSIONS

Muscle: Juvenile (Young Investigators’ Symposium)

Muscle: Mechanics

Muscle: Close-up

Muscle: Cytoskeleton

Muscle: Mechanobiology

Muscle: Outside-in

Muscle: Skeletal

Muscle: Heart



SHORT PROGRAMME

EMC2019_FinalProgramme.jpg

DETAILED PROGRAMME


 

PROGRAMME

 

Saturday 7 September 2019

 

Young Investigator Symposium

 

(organised by Neil KAD & Luca FUSI)

 

12-12.15: Welcome and Coffee

 

12.15-13.45: Session I (chaired by David WARSHAW)

 

12.15: Pragati PANDEY (Imperial College London, UK): Engineered Heart Tissue for Cardiac Regeneration

 

12.30: Matthew STROUD (King’s College London, UK): Establishing new role(s) for the nuclear envelope in the mammalian heart

 

12.45: Natalie WEBER (Hannover Medical School, Germany): Pluripotent stem cell-derived cardiomyocytes from a patient with Arg723Gly β- myosin heavy chain mutation as model for Hypertrophic Cardiomyopathy?

 

13.00: Aseem SALHOTRA (Linnaeus University, Sweden): Actin-myosin function and longevity in nano devices

 

13.15: Tatiana MYACHINA (Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Russia): Interventricular differences in contractile function in experimental type 1 diabetes

 

13.30: Alyssa GROGAN (University of Maryland, Baltimore, USA): Expression of truncated obscurins leads to maladaptove responses in the heart

 

13.45-14.00: Coffee Break

 

14.00-15.30: Session II (chaired by Chiara TESI)

 

14.00: Martijn van de LOCHT (Amsterdam UMC, Netherlands): Mutations in fast skeletal troponin C (TNNC2) cause contractile dysfunction

 

14.15: Irene PERTICI (University of Florence, Italy): A synthetic nanomachine (Myomac) used to define the functional diversity of muscle myosin isoforms

 

14.30: André TOMALKA (University of Stuttgart, Germany): Differences between cardiac and skeletal musculature: eccentric force generation and muscle structure

 

14.45: Stefan CONIJN (Amsterdam UMC, Netherlands): Mutation in KBTBD13 causes stiffening of thin filaments in skeletal muscle

 

15.00: Chloe JOHNSON (University of Kent, UK): Making a human myosin behave like a rat

 

15.15: Jishnu KRISHNAN (University of Alaska Fairbanks, USA): Effects of diet and hypothermia on skeletal muscle contractile function in hibernating animals

 

15.30-15.45: Coffee Break

 

15.45-16.45: Careers Session

 

15.45: David WARSHAW

 

15.55: Katja GEHMLICH

 

16.05: Panel Discussion

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Saturday 7 September 2019

 

Main Conference

 

17.00: Welcome session: Elisabeth EHLER and Michael GEEVES

 

17.30-18.30: 1st Jean Hanson Keynote Lecture: Prof Malcolm IRVING FRS (Randall Centre for Cell and Molecular Biophysics, King’s College London, UK): Regulation of myosin motors in skeletal muscle and in the heart

 

18.30: Welcome drinks

 

Sunday 8 September 2019:

 

SESSION I: Muscle - Mechanics

 

Session Chairs: Michael GEEVES & Michael REGNIER

 

9.00-9.30: Michael REGNIER (University of Washington, USA): Motivating Myosin: 2-deoxy-ATP Induced Structural Alterations that Increase Myosin Activity

 

9.30-10.00: James SPUDICH (Stanford University, USA): The myosin mesa and hypertrophic cardiomyopathy: Mutations to mechanisms to therapies

 

10.00-10.15: John SQUIRE (University of Bristol & Imperial College, UK): The T1 curve of Huxley and Simmons (1971) reassessed.

 

10.15-10.30: Massimo RECONDITI (University of Florence, Italy): Low temperature traps myosin motors of mammalian muscle in a state that prevents activation

 

10.30-11.15: Coffee Break

 

11.15-11.30: Luca FUSI (King’s College London, UK): The role of stretch-induced structural changes of the thick filaments in length-dependent activation in cardiac muscle

 

11.30-11.45: Chiara TESI (University of Florence, Italy): Time resolved depression of isometric force by Mavacamten in single myofibrils from rabbit psoas and human cardiac muscle

 

11.45-12.00: Oleg MATUSOVSKY (McGill University, Canada): Dynamics of cardiac thin filaments upon Ca2+ activation and heavy meromyosin binding revealed by high-speed atomic force microscopy

 

12.00-12.10: Alf MÅNSSON (Linnaeus University, Sweden): Effects of inorganic phosphate on muscle contraction - a case where either model or experiments may be right

 

12.10-12.20: Brian MacINTOSH (University of Calgary, Canada): Does Ca2++ sensitivity increase during staircase with intermittent submaximal tetanic contractions?

 

12.20-12.30: Seong-won HAN (University of Calgary, Canada): Does the amount of stretching affect residual force enhancement in cardiac myofibrils?

 

 

12.30-13.30: Sandwich Lunch

 

SESSION II: Muscle - Close-up

 

 

Session Chairs: Michelle PECKHAM & Gregory ALUSHIN

 

13.30-14.00: Michelle PECKHAM (University of Leeds, UK): Using novel super-resolution imaging approaches to investigate protein organisation in the Z-disc in cardiomyocytes

 

14.00-14.30: Gregory ALUSHIN (The Rockefeller University, USA): Myosin XV modulates F-actin structure to promote filament polymerization and stereocilium elongation

 

14.30-15.00: Coffee Break

 

15.00-15.15: Pauline BENNETT (King’s College London, UK): Locating titin on the muscle thick filament

 

15.15-15.30: Izzy JAYASINGHE (University of Leeds, UK): Super-resolution 3D mapping of site-specific phosphorylation signatures of ryanodine receptors in the healthy and failing heart

 

15.30-15.45: Steven MARSTON (Imperial College London, UK): Molecular dynamics simulations of cardiac troponin show that phosphorylation stabilizes the ‘open’state and that mutations disrupt this relationship

 

15.45-16.00: Coen OTTENHEIJM (VUMC Amsterdam, Netherlands): Localisation of individual nebulin molecules in sarcomeres of nebulin-DENDRA2 KI mice

 

 

 

16.00-17.00: Keynote Lecture: Prof Jil TARDIFF (Sarver Heart Center, University of Arizona, USA): Walking a Thin Line:  Intrinsic and Extrinsic Modulators of Cardiac Thin Filament Function in Health and Disease

 

 

17.00-18.00: Annual General Meeting of European Society of Muscle Research (Wolfgang LINKE)

 

 

 

Poster session 1

 

18.00-20.00: I, II, III, VI (Beer & Wine)

 

 

 

Monday 9 September 2019:

 

 

SESSION III: Muscle - Cytoskeleton

 

Session Chairs: Martina KRÜGER & Farah SHEIKH

 

9.00-9.30: Farah SHEIKH (UCSD, USA): Policing cell-cell connections: A novel role for the COP9 signalosome in arrhythmogenic heart disease

 

9.30-10.00: Matthew CAPORIZZO (University of Pennsylvania, USA): The pathological contribution of detyronisated microtubules to human myocardial mechanics

 

10.00-10.20: Wolfgang LINKE (Münster University, Germany): Re-evaluation of the contribution from titin to cardiomyocyte viscoelasticity using a mouse model that allows specific cleavage of the titin springs

 

10.20-10.50: Coffee break

 

10.50-11.10: Katja GEHMLICH (University of Birmingham, UK): Titin A178D causes cardiomyopathy in mice through loss of telethonin

 

11.10-11.30: Stephan LANGE (UCSD, USA): Obscurin/Obsl1 double knockouts - a new genetic model for HFpEF?

 

11.30-11.50: Manuel TAFT (Hannover Medical School, Germany): Myosin 18B regulates sarcomeric myosin dynamics and actin thin filament organisation during cardiac myofibril assembly

 

11.50-12.10: Jim SELLERS (NHLBI, NIH, USA): Mechanical properties of nonmuscle myosin 2

 

12.10-12.30: Alexander MATYUSHENKO (Federal Research Centre «Fundamentals Of Biotechnology» Of The Russian Academy Of Sciences, Russia): Unique properties of brain-specific tropomyosin isoforms

 

12.30-13.30: Sandwich Lunch

 

SESSION IV: Muscle - Mechanobiology

 

 

Session Chairs: Derek WARREN & Thomas ISKRATSCH

 

13.30-14.00: Frank SCHNORRER (Aix Marseille University, CNRS, IBDM, France): Do titins rule sarcomeres of insect muscles?

 

14.00-14.15: Frieder SCHÖCK (McGill University, Canada): Sarcomere growth is controlled by a finely tuned mechanism of protein aggregation

 

14.15-14.30: Arianna FORNILI (Queen Mary University of London, UK): In silico observation of mechanically-induced binding pockets in muscle proteins

 

14.30-15.00: Coffee Break

 

15.00-15.30: Derek WARREN (University of East Anglia, UK) Emerging regulators of vascular smooth muscle cell migration

 

15.30-15.45: Thomas ISKRATSCH (Queen Mary University of London, UK): Cardiomyocyte integrin mechanosignalling: Responses to a dynamic extracellular matrix in development and disease

 

15.45-16.00: Christopher SOLIS (University of Illinois at Chicago, USA): Sarcomere disassembly after unloading is regulated by ubiquitination and acetylation of CapZ and alpha-actinin

 

 

16.00-17.00: Keynote Lecture: Prof Nadia ROSENTHAL (The Jackson Laboratory, USA): New strategies for accelerating muscle regeneration



18.00: Departure of bus to Canterbury Cathedral (booked attendees only)

18.30: Reception followed by Conference Dinner (booked attendees only)

 

 

Tuesday 10 September 2019:

 

SESSION V: Muscle - Outside in

 

Session Chairs: Ashraf KITMITTO & Nordine HELASSA

 

 

9.00-9.30: Leonardo SACCONI (The Biophysics Biophotonics Lab, LENS, Italy): Interplay between T-Tubular electrical defects and sub-cellular alterations of calcium release in cardiac diseases

 

9.30-10.00: Aphrodite VASILAKI (University of Liverpool, UK): Physiological and structural changes in skeletal muscle and nerve-muscle interactions: the effects of nutrition and ageing

 

10.00-10.30: David WARSHAW (University of Vermont, USA): Myosin Binding Protein-C: Stepping on both the gas and brake to regulate muscle contractility

 

10.30-11.00: Coffee Break

 

11.00-11.20: Simone SPINOZZI (UCSD, USA): Nexilin is essential for cardiac T-tubules development

 

11.20-11.40: Vincenzo SORRENTINO (University of Siena, Italy): Homo- and heteromeric interactions determine junctophilins retention at adult skeletal muscle triads

 

11.40-12.00: Feliciano PROTASI (University G. d'Annunzio of Chieti-Pescara, Italy): Assembly of Ca2+ entry units provides constitutively active store-operated Ca2+ entry

 

12.00-12.20: Antonio MICHELUCCI (University of Rochester, USA): Muscles from calsequestrin-1 knockout mice contain pre- assembled Calcium Entry Units that provide constitutively active store-operated Ca2+ entry

 

 

12.30-13.30: Sandwich Lunch

 

 

SESSION VI: Muscle  - Skeletal

 

 

Session Chairs: Christina KARATZAFERI & John HUNT

 

13.30-13.35: Christina KARATZAFERI (Uuniversity of Thessaly, Greece): Introduction

 

13.35-13.50: John HUNT (Nottingham Trent University, UK): To repair, replace, augment and regenerate

 

13.50-14.00: Rokas MIKSIUNAS (Centre for Innovative Medicine, Lithuania): The effect of heat shock on myogenic differentiation of human skeletal mesenchymal stem cells

 

14.00-14.10: Amy PASCOE (La Trobe University, Australia): Myogenic effects of Fn14 targeting antibodies in a mouse skeletal muscle Notexin model

 

14.10-14.20: Antonio SPONGA (University of Vienna, Austria): Structure of alpha-actinin/FATZ-1 fuzzy complex and implications in Z-disk assembly

 

14.20-14.30: Robbert VAN DER PIJL (University of Arizona, USA): Molecular regulation of longitudinal muscle hypertrophy, titin mechanosensing in action

 

14.30-15.00: Coffee Break

 

15.00-15.15: Katarzyna ROBASZKIEWICZ (Kazimierz Wielki University in Bydgoszcz, Poland): Regulation of actin filament dynamics by cofilin-2 and tropomyosin isoforms Tpm1.1 and Tpm 3.12

 

15.15-15.30: Lars LARSSON (Karolinska Institutet, Sweden): Bench to bedside research in critical illness myopathy and ventilator induced diaphragm muscle dysfunction

 

15.30-15.40: Ruth ELLER (University Medicine Greifswald, Germany): Deletion of the cation channel TRPV4 attenuates fibrosis in dystrophic mdx mouse muscle

 

15.40-15.55: Yoshitsugu AOKI (National Center of Neurology and Psychiatry, Japan): Advanced PPMO combinations drive multi-exon skipping and dystrophin expression in dystrophic dogs

 

15.55-16.05: Alex ADDINSALL (Karolinska Institutet, Sweden): The reduction of selenoprotein S impairs muscle performance independent of dysregulated cellular or inflammatory stress

 

16.05-16.20: Hans DEGENS (Manchester Metropolitan University, UK): The role of the microcirculation in muscle function and plasticity

 

16.20: Closing Remarks

 

16.30-17.00: Dr Aida LLAURO PORTELL (LUMICKS, The Netherlands): Combining optical tweezers with fluorescence microscopy and IRM for the study of cytoskeletal processes

 

 

Poster session 2

 

16.30-18.00: IV, V, VII (Beer & Wine)

 

 

Wednesday 11 September 2019:

 

SESSION VII: Muscle - Cardiac

 

 

Session Chairs: Mathias GAUTEL & Friederike CUELLO

 

9.00-9.15: Roua HASSOUN (Ruhr-University Bochum, Germany): The newly detected Myosin binding protein C/Troponin interaction, function and thin filaments affected by cTn mutants

 

9.15-9.45: Mathias MERICSKAY (Université Paris-Saclay, France): Nicotinamide riboside metabolism and cardiac function

 

9.45-10.00: Maria PAPADAKI (Loyola University Chicago, USA): Molecular Mechanisms and Therapeutic Approaches to Myofilament Glycation as a result of diabetes

 

10.00-10.15: Veronika TIBENSKA (Charles University, Czech Republic): Effect of gradual cold acclimation on beta-adrenergic signalling in rat heart

 

10.15-10.30: Xenia BUTOVA (Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Russia): A study of heterogeneity in mechanical activity of single cardiomyocytes and contractile proteins from rat atria and ventricles

 

10.30-11.00 Coffee Break

 

11.00-11.30: Thomas KAMPOURAKIS (King’s College London): Shortening-induced de-activation of the thick filaments in cardiac muscle

 

11.30-11.45: Paul GOLDSPINK (University of Illinois Chicago, USA): Deamidation of Asparagine14 prevents phosphorylation of human cardiac myosin light chain 2

 

11.45-12.00: Suman NAG (MyoKardia, USA): Phosphorylation and Binding of Ca2+ to RLC, Counters the Effect of Mavacamten by Destabilizing the Myosin Super- Relaxed State

 

12.00-12.15: Paul ROBINSON (University of Oxford, UK): Measurement of myofilament-localised calcium dynamics in adult cardiomyocytes to assess the effect of small molecule treatments for HCM

 

12.15-12.30: Elisabetta BRUNELLO (King’s College London, UK): Structural dynamics of the myosin filament during activation and relaxation of heart muscle cells

 

 

12.30: Prize Giving and Final Remarks

 

13.00: Sandwich Lunch